Identification of a Novel Tumor Suppressor Gene p34 on Human Chromosome 6q25.1
نویسندگان
چکیده
منابع مشابه
Novel tumor suppressor locus in human chromosome region 3p14.2.
BACKGROUND Alterations of chromosome region 3p14 are observed in numerous human malignancies. Because the pattern of allelic losses suggests the existence of at least one tumor suppressor gene within this region, we established a library of yeast artificial chromosomes (YACs) containing contiguous human 3p14 sequences to permit a search for tumor suppressor loci within the 3p14 region by use of...
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A second tumor suppressor locus on 17p that is distinct from TP53 has been identified in brain, breast, lung, and ovarian tumors. Using allelic loss mapping and positional cloning methods, we have recently identified two novel genes, which we refer to as OVCA1 and OVCA2, that map to 17p13.3. The two genes are ubiquitously expressed and encode proteins of 443 and 227 amino acids, respectively, w...
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A second tumor suppressor locus on 17p that is distinct from 77*5.1has been identified in brain, breast, lung, and ovarian tumors. Using allelic loss mapping and positional cloning methods, we have recently identified two novel genes, which we refer to as OVCAI and OVCA2, that map to 17pl3.3. The two genes are ubiquitously expressed and encode proteins of 443 and 227 amino acids, respectively, ...
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Considerable molecular genetic and cytogenetic evidence indicates that chromosome 11 is a target for chromosome breakage, rearrangement, and loss during the development of human malignant melanomas. Abnormalities of the long arm of chromosome 11 are also evident in a wide variety of other human solid tumors, including carcinomas of the breast, ovary, cervix, and lung. In melanomas, these abnorm...
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Considerable molecular genetic and cytogenetic evidence indicates that chromosome 11 is a target for chromosome breakage, rearrangement, and loss during the development of human malignant melanomas. Abnormal ities of the long arm of chromosome 11 are also evident in a wide variety of other human solid tumors, including carcinomas of the breast, ovary, cervix, and lung. In melanomas, these abnor...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2007
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-06-2723